As of Q4'25, RXRX's latest reported Operating ROA stands at -7.33%, with ROE at -9.56% and ROIC at -8.04%. These negative values indicate continued challenges in generating returns on assets, equity, and invested capital through the end of 2025. From Q1'23 to Q4'25, the chart shows that all three profitability ratios—ROA, ROE, and ROIC—remained negative throughout the period, reflecting persistent operational losses. However, there is a notable improvement in the most recent quarters: ROA improved from a low of -16.38% in Q1'24 to -7.33% in Q4'25, while ROE and ROIC also show similar upward trends. This suggests that, although RXRX is still operating at a loss, the magnitude of those losses is decreasing, pointing to gradual operational recovery over the observed timeframe.