As of Q4'25, RXRX reported a Gross Margin of 102.1%, an Operating Margin of -304.9%, and a Net Profit Margin of -304.3%. This marks a significant positive spike in Gross Margin, while both Operating and Net Profit Margins remain deeply negative, though less so than the extreme lows seen in earlier quarters. From Q1'23 to Q4'25, the chart reveals considerable volatility across all margin metrics. Gross Margin fluctuated sharply, turning negative in several quarters before surging above 100% in Q4'25. Operating and Net Profit Margins consistently remained negative, with pronounced declines in Q4'24 and Q3'25 (Operating Margin at -4042.4% and -3327.6%, Net Profit Margin at -3935.5% and -3135.3%, respectively), before partially recovering by Q4'25. Overall, the trend indicates persistent profitability challenges for RXRX, despite occasional improvements in Gross Margin.