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Septerna, inc.SEPN.US Overview

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SEPN Recent Performance

-3.19%

Septerna, inc.

-1.10%

Avg of Sector

-0.49%

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SEPN Key Information

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SEPN Profile

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products candidates for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. The company develops SEP-786, an oral small molecule PTH1R agonist for hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 NAM for chronic spontaneous urticaria and other mast cell diseases; TSHR Program, an oral small molecule TSHR NAM for Graves' disease and thyroid eye disease. It also develops oral small molecule single- and multi-incretin receptor agonists for metabolic disorders including obesity and type 2 diabetes. Septerna, Inc. was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. The company was incorporated in 2019 and is headquartered in South San Francisco, California.

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SEPN FAQ

This disclaimer is provided by TradingValley Inc. and includes any messages, news, research, analysis, prices or other information provided by the Company's website, the application "Growin App" and other services provided through the Company's website. It is only general market information for educational and investment decision-making reference, and does not constitute any investment advice. View Growin Disclaimer

SEPN Earnings Table

Unit : USD

QTRNon-GAAP EPSEPS YoYEPS Surprise %SalesSales YoYSales Surprise %NPM
Current
2025Q4
2025Q3
2025Q2
2025Q1
METRIC
VALUE
vs. INDUSTRY
EPS (TTM)
-0.06
PE Ratio (TTM)
-
Forward PE
107.53
PS Ratio (TTM)
24.11
PB Ratio
2.94
Price-to-FCF
7.33
METRIC
VALUE
vs. INDUSTRY
Gross Margin
100.00%
Net Margin
-5.62%
Revenue Growth (YoY)
13394.97%
Profit Growth (YoY)
13394.97%
3-Year Revenue Growth
415.56%
3-Year Profit Growth
415.56%
METRIC
VALUE
vs. INDUSTRY
EPS (TTM)
-0.06
PE Ratio (TTM)
-
Forward PE
107.53
PS Ratio (TTM)
24.11
PB Ratio
2.94
Price-to-FCF
7.33
Gross Margin
100.00%
Net Margin
-5.62%
Revenue Growth (YoY)
13394.97%
Profit Growth (YoY)
13394.97%
3-Year Revenue Growth
415.56%
3-Year Profit Growth
415.56%
  • When is SEPN's latest earnings report released?

    The most recent financial report for Septerna, inc. (SEPN) covers the period of 2025Q4 and was published on 2025/12/31. This report is prepared according to IFRS/US GAAP standards and includes key financial indicators—Revenue, Profitability, Cash Flow, and Capital Structure. This information is essential for investors evaluating SEPN's short-term business performance and financial health. For the latest updates on SEPN's earnings releases, visit this page regularly.

  • What is the operating profit of SEPN?

    According to the latest financial report, Septerna, inc. (SEPN) reported an Operating Profit of -16.02M with an Operating Margin of -66.44% this period, representing a growth of 35.18% compared to the same period last year. Operating Profit reflects the company's core business efficiency and cost control, making it a key indicator for evaluating operational strength and profitability.

  • How is SEPN's revenue growth?

    In the latest financial report, Septerna, inc. (SEPN) announced revenue of 24.12M, with a Year-Over-Year growth rate of 11,276.42%. Revenue growth can be driven by product mix changes, market share expansion, price adjustments, or international market penetration. Investors should also monitor gross margin and regional revenue distribution for a comprehensive view of growth quality and sustainability.

  • How much debt does SEPN have?

    As of the end of the reporting period, Septerna, inc. (SEPN) had total debt of 23.63M, with a debt ratio of 0.04. Long-term debt comprises a higher/lower proportion. The level of financial leverage directly impacts the company's capital structure and interest coverage. If debt is high, pay attention to interest expenses and refinancing risks. Conversely, a low-leverage structure indicates greater risk tolerance but potentially less growth flexibility.

  • How much cash does SEPN have?

    At the end of the period, Septerna, inc. (SEPN) held Total Cash and Cash Equivalents of 121.63M, accounting for 0.2 of total assets. Both current and quick ratios indicate robust short-term debt repayment ability. High cash reserves typically mean the company has strong liquidity, supporting operational needs, expansion investments, or shareholder returns.

  • Does SEPN go with three margins increasing?

    In the latest report, Septerna, inc. (SEPN) did not achieve the “three margins increasing” benchmark, with a gross margin of 100%%, operating margin of -66.44%%, and net margin of -44.5%%. This demonstrates limited improvement in profitability, which is a key signal for fundamental analysis. Investors should consider margin trends alongside other financial indicators to assess SEPN's profit trajectory and future growth potential.

  • Is SEPN's EPS continuing to grow?

    According to the past four quarterly reports, Septerna, inc. (SEPN)'s earnings per share (EPS) shows a declining trend, with the latest EPS at -0.24. If EPS continues to rise due to revenue growth and cost optimization, it can support P/E valuation recovery and attract long-term investors.

  • What is the FCF of SEPN?

    Septerna, inc. (SEPN)'s Free Cash Flow (FCF) for the period is -15.05M, calculated as Operating Cash Flow minus Capital Expenditures, representing a rise of 30.21% compared with the previous period. Positive FCF growth provides stable funding for dividends, debt repayment, or strategic acquisitions, and is an important measure of true profitability and shareholder return potential.

  • What are the PEG ratio and PE ratio of SEPN?

    The latest valuation data shows Septerna, inc. (SEPN) has a Price-To-Earnings (PE) ratio of -26.7 and a Price/Earnings-To-Growth (PEG) ratio of 0.12. A PEG below 1 usually suggests the market is underestimating growth potential, while a PEG above 1 indicates high growth expectations are already priced in. Investors should conduct a comprehensive valuation by considering historical growth, market forecasts, and industry cycles.