The latest data point for ABBV's operating ROA metrics in Q4'25 shows ROE at -55.5%, ROA at 1.4%, and ROIC at 3.8%, indicating a mixed performance with ROE remaining deeply negative while ROA and ROIC reflect modest positive returns on assets and invested capital. Over the period from Q1'23 to Q4'25, ROE exhibited significant volatility, starting at 1.8% and peaking at 90.6% in Q1'25 before plunging to -512.6% in Q2'25 and stabilizing in negative territory thereafter, suggesting challenges in equity efficiency possibly due to one-time events. In contrast, ROA remained relatively stable and low, fluctuating between -0.02% and 1.4% with a slight upward trend in the final quarter, while ROIC showed a more consistent positive trajectory, rising from 0.9% to 3.8% overall but with dips in Q4'24 and Q3'25, highlighting improving capital utilization amid operational pressures.